Dupilumab Provides Acceptable Long-Term Safety and Efficacy in Children Aged ≥ 6 to < 12 Years with Uncontrolled, Severe Atopic Dermatitis
نویسندگان
چکیده
منابع مشابه
Efficacy and safety of dupilumab for the treatment of moderate-to-severe atopic dermatitis in adults
Objective Atopic dermatitis is a chronic, relapsing inflammatory skin disease characterized by intense pruritus, excoriations and limited therapies. Dupilumab, a monoclonal antibody against interleukin-4 receptor alpha, is a promising new treatment option for atopic dermatitis. We sought to systematically summarize the efficacy, safety, and influence on quality of life of dupilumab for the trea...
متن کاملDupilumab treatment in adults with moderate-to-severe atopic dermatitis.
BACKGROUND Dupilumab, a fully human monoclonal antibody that blocks interleukin-4 and interleukin-13, has shown efficacy in patients with asthma and elevated eosinophil levels. The blockade by dupilumab of these key drivers of type 2 helper T-cell (Th2)-mediated inflammation could help in the treatment of related diseases, including atopic dermatitis. METHODS We performed randomized, double-b...
متن کاملEfficacy and safety of pimecrolimus cream in the long-term management of atopic dermatitis in children.
OBJECTIVE Pimecrolimus cream (SDZ ASM 981), a nonsteroid inhibitor of inflammatory cytokines, is effective in atopic dermatitis (AD). We assessed whether early treatment of AD signs/symptoms with pimecrolimus could influence long-term outcome by preventing disease flares. METHODS Early intervention with pimecrolimus was compared with a conventional AD treatment strategy (ie, emollients and to...
متن کاملLong-term safety and efficacy of tacrolimus ointment for the treatment of atopic dermatitis in children.
Tacrolimus ointment is a nonsteroidal topical immunomodulator that was formulated specifically for the treatment of atopic dermatitis. A total of 255 children, 2 to 15 years of age, with moderate to severe atopic dermatitis applied 0.1% tacrolimus ointment twice daily for up to 12 months to assess long-term safety and efficacy. Patients on average were treated with tacrolimus ointment for 279 d...
متن کاملAntipyretic efficacy of acetaminophen and ibuprofen in children aged 6 months to 10 years
Introduction: Fever and consequent convulsion are among major concerns for parents of febrile children. Many antipyretic drugs are applied excessively to decrease fever in children. This research is designed to study the efficacy and stability effects of cetaminophen and Ibuprofen in febrile children aged 6 months to 10 years old. Methods: This single-blind clinical trial study was performed o...
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ژورنال
عنوان ژورنال: SKIN The Journal of Cutaneous Medicine
سال: 2020
ISSN: 2574-1624
DOI: 10.25251/skin.4.supp.104